Single dose fMRI effects of Guanfacine and Lisdexamfetamine in ADHD
Overview
Do you have ADHD? Are you between 8 and 20 years old?
What is it about?
This study looks at two different types of medication that are sometimes used in treatment of children with Attention Deficit Hyperactivity Disorder (The medications we are studying are called Lisdexamfetamine and Guanfacine). We would like to find out how these two drugs act on the brain of young people with ADHD. This is where you can help us!
What would I have to do?
This is a Magnetic Resonance Imaging (study which means that you will be asked to come to the Centre for Neuroimaging Sciences at Denmark Hill to have some brain scans. You will be asked to carry out some computer tasks while lying still in the scanner.
We would like you to come in for four days within three weeks i.e. for a screening appointment and three scans separated by a week each. We know this is quite a lot to ask, so we will compensate you for your time (you will get £20 for the screening appointment and £50 for each scan, i.e. a total of £170. We can also give you a picture of your brain!
We are looking for boys and girls with ADHD. Please note that we CANNOT scan you if you have braces or have history of cardiac problems. The MRI machine contains a giant magnet but it is very safe, which is why it is very useful for research with children and adolescents. You can download ‘My MRI Journey’ (a free app showing you exactly what happens on the day of your MRI visit)!
Are you interested in taking part in this study?
Planned end date
31 Mar 2025 10:16Conditions
ADHDInclusion Criteria
- Age range: 10-18 years
- Gender: male
- Medication-naïve or on no medication for at least a year
- Handedness: right-handed
- Weight: 25-80 kg
- Meeting DSM-5 diagnosis of ADHD
- Score above clinical cut-off on the ADHD module of the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) (Kaufman et al., 1997)
- Score below clinical cut-off for ASD on the Social Communication Questionnaire (SCQ) (Rutter et al., 2003)
- Score above clinical cut-off for ADHD on the short forms of the Conners Parent Rating Scales, CPRS (Conners et al., 2008)
- Score above cut-off on the ADHD Rating Scale, ADHD-RS (DuPaul, et al., 1998)
- IQ > 80 as tested on the WASI-II (Wechsler et al., 1999)
Mood and depression symptoms, phobias, anxiety, conduct disorder, oppositional defiant disorder, and eating disorders will be allowed.
