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National services

Child and adolescent services

National services

Child and adolescent services

National services

Child and adolescent services

National services

Child and adolescent services

Centre for Interventional Paediatric Psychopharmacology and Rare Diseases (CIPPRD)

Maudsley Hospital

Contact information: 

Michael Rutter Centre

De Crespigny Park

Call: 020 3228 3900


Mode: Outpatient

Referrals are accepted from:
NHS consultant child and adolescent psychiatrists or consultant paediatricians as part of a shared care arrangement with local child and adolescent mental health services (CAMHS) or paediatrics (with CAMHS support).

Referrals received from medical specialists or GPs will need to be supported by local CAMHS or Paediatrics.


The Centre of Interventional Paediatric Psychopharmacology and Rare Diseases (CIPPRD) provides whole-person medicine and integrated mental and physical health care using clinically cost-effective and innovative interventions alongside patient involvement for children and young people with complex, severe, and treatment-resistant co-occurring neuropsychiatric disorders, and medical conditions including rare diseases.

This service provides highly specialist assessment, pharmacological and psychological treatment for children with a variety of complex neuropsychiatric disorders. This is in the context of neuroinflammatory, metabolic, genetic or neurodegenerative disorders and acquired brain injury; psychotropic-induced side-effects and neuropsychiatric aspects in children with terminal illness.

We have specific programs for those with emotional behavioural autonomic dysregulation (EBAD), Rett syndrome, mucopolysaccharidoses, and other rare disorders. Intervention is based on a bio-psycho-social approach, with focus on the psychopharmacological and cognitive-behavioural models.

We have recently set up the world’s first Centre for Personalised Medicine for Rett Syndrome (CPMRS), a new service that provides neuropsychiatric services for Rett syndrome patients across the life span. The CPMRS focusses on providing holistic specialist care, conducting clinical trials, and developing digital health strategies to monitor and manage patients, whilst conducting research.

The service provides holistic care and closely liaises with other specialties such as cardiology, neurology, endocrinology, ophthalmology, as Rett syndrome is a multi-systemic disorder. The CPMRS is recognised as an international centre of excellence in providing care for Rett syndrome.

Our specialist research team (Centre for Interventional Paediatric Psychopharmacology Research Team), led by Professor Paramala Santosh, focusses on translational research that includes conducting clinical trials in rare diseases such as Rett syndrome; developing patient centred outcome measures (PCOMs) and digital health monitoring using the HealthTrackerTM platform, and sensor-based monitoring of autonomic function using wearable technology.

We also conduct research on the pharmacology of paediatric neurodegeneration in a number of rare disorders. We have used machine learning approaches to assessing and managing emotional, behavioural and autonomic dysregulation (EBAD), which is common to complex multiple co-morbidity, acquired brain injury, and many rare disorders.

A diagram that shows the multi-organisational collaboration that is involved in providing holistic CIPPRD care is shown below:
CIPPD structure